Publications

2022

Nader Atlasy, Anna Bujko, Espen S. Bækkevold, Peter Brazda, Eva Janssen-Megens, Knut E. A. Lundin, Jørgen Jahnsen, Frode L. Jahnsen & Hendrik G. Stunnenberg, Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease. Nat Commun 13, 4920 (2022). https://doi.org/10.1038/s41467-022-32691-5

Bastian Fromm, Eirik Høye, Diana Domanska, Xiangfu Zhong, Ernesto Aparicio-Puerta, Vladimir Ovchinnikov, Sinan U Umu, Peter J Chabot, Wenjing Kang, Morteza Aslanzadeh, Marcel Tarbier, Emilio Mármol-Sánchez, Gianvito Urgese, Morten Johansen, Eivind Hovig, Michael Hackenberg, Marc R Friedländer, Kevin J Peterson, MirGeneDB 2.1: toward a complete sampling of all major animal phyla, Nucleic Acids Research, Volume 50, Issue D1, 7 January 2022, Pages D204–D210, https://doi.org/10.1093/nar/gkab1101

Eirik Høye, Bastian Fromm, Paul HM Böttger, Diana Domanska, Annette Torgunrud, Christin Lund-Andersen, Torveig Weum Abrahamsen, Åsmund Avdem Fretland, Vegar J Dagenborg, Susanne Lorenz, Bjørn Edwin, Eivind Hovig, Kjersti Flatmark, A comprehensive framework for analysis of microRNA sequencing data in metastatic colorectal cancer, NAR Cancer, Volume 4, Issue 1, March 2022, zcab051, https://doi.org/10.1093/narcan/zcab051

Diana Domanska, Umair Majid, Victoria T. Karlsen, Marianne A. Merok, Ann-Christin Røberg Beitnes, Sheraz Yaqub, Espen S. Bækkevold, Frode L. Jahnsen; Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets. J Exp Med 7 March 2022; 219 (3): e20211846. doi: https://doi.org/10.1084/jem.20211846

Aasebo AT, Gedde- Dahl T, Reims HM, Baekkevold ES, Jahnsen FL, Calprotectin expressing donor-derived macrophages increase in acute gastrointestinal graft versus host disease, Transplantation and Cellular Therapy, 2022, ISSN 2666-6367, https://doi.org/10.1016/j.jtct.2022.01.028.

2021

Solhaug MB, Schreurs O, Schenck K, Blix IJ, Baekkevold ES (2021). Origin of langerin (CD207)-expressing antigen presenting cells in the normal oral mucosa and in oral lichen planus lesions. Eur J Oral Sci. PubMed 34935212 DOI 10.1111/eos.12835

Bartolomé-Casado R, Bækkevold ES, Jahnsen FL (2021). Response to Lauro and Zorzetti. Mucosal Immunol, 14 (6), 1395-1396. PubMed 34535772 DOI 10.1038/s41385-021-00454-y

Jahnsen FL, Johansen FE (2021). Legends of allergology and immunology: Per Brandtzaeg – Pillar of mucosal immunology. Allergy, 76 (8), 2634-2635. PubMed 33752264 DOI 10.1111/all.14824

Sikkeland LIB, Qiao SW, Ueland T, Myrdal O, Wyrożemski Ł, Aukrust P, Jahnsen FL, Sjåheim T, Kongerud J, Molberg Ø, Lund MB, Bækkevold ES (2021) Lung CD4+ T-cells in patients with lung fibrosis produce pro-fibrotic interleukin-13 together with interferon-γ Eur Respir J, 57 (3) PubMed 33154027 DOI 10.1183/13993003.00983-2020

2020

Safavi S, Larouche A, Zahn A, Patenaude AM, Domanska D, Dionne K, Rognes T, Dingler F, Kang SK, Liu Y, Johnson N, Hébert J, Verdun RE, Rada CA, Vega F, Nilsen H, Di Noia JM. The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID. NAR Cancer. 2020 Aug 27;2(3):zcaa019. doi: 10.1093/narcan/zcaa019. Erratum in: NAR Cancer. 2021 Jan 06;3(1):zcaa045. PMID: 33554121; PMCID: PMC7848951.

Bern M, Nilsen J, Ferrarese M, Sand KMK, Gjølberg TT, Lode HE, Davidson RJ, Camire RM, Bækkevold ES, Foss S, Grevys A, Dalhus B, Wilson J, Høydahl LS, Christianson GJ, Roopenian DC, Schlothauer T, Michaelsen TE, Moe MC, Lombardi S, Pinotti M, Sandlie I, Branchini A, Andersen JT (2020). An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics. Sci Transl Med, 12 (565). PubMed 33055243 DOI 10.1126/scitranslmed.abb0580

Bartolomé-Casado R, Landsverk OJB, Chauhan SK, Sætre F, Hagen KT, Yaqub S, Øyen O, Horneland R, Aandahl EM, Aabakken L, Bækkevold ES, Jahnsen FL (2020). CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile. Mucosal Immunol, 14 (2), 402-410. PubMed 32572129 DOI 10.1038/s41385-020-0315-5

Divito SJ, Aasebø AT, Matos TR, Hsieh PC, Collin M, Elco CP, O’Malley JT, Bækkevold ES, Reims H, Gedde-Dahl T, Hagerstrom M, Hilaire J, Lian JW, Milford EL, Pinkus GS, Ho VT, Soiffer RJ, Kim HT, Mihm MC, Ritz J, Guleria I, Cutler CS, Clark RA, Jahnsen FL, Kupper TS (2020). Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease. J Clin Invest, 130 (9), 4624-4636. PubMed 32516138 DOI 10.1172/JCI129965

Fretheim H, Chung BK, Didriksen H, Bækkevold ES, Midtvedt Ø, Brunborg C, Holm K, Valeur J, Tennøe AH, Garen T, Midtvedt T, Trøseid M, Zarè H, Lund MB, Hov JR, Lundin KEA, Molberg Ø, Hoffmann-Vold AM (2020). Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial. PLoS One, 15 (5), e0232739. PubMed 32437393 DOI 10.1371/journal.pone.0232739

Melhus G, Brorson SH, Baekkevold ES, Andersson G, Jemtland R, Olstad OK, Reinholt FP (2010)nGene expression and distribution of key bone turnover markers in the callus of estrogen-deficient, vitamin D-depleted ratsnCalcif Tissue Int, 87 (1), 77-89nPubMed 20495792 DOI 10.1007/s00223-010-9371-2

2019

Seiron P, Wiberg A, Kuric E, Krogvold L, Jahnsen FL, Dahl-Jørgensen K, Skog O, Korsgren O (2019). Characterisation of the endocrine pancreas in type 1 diabetes: islet size is maintained but islet number is markedly reduced. J Pathol Clin Res, 5 (4), 248-255. PubMed 31493350 DOI 10.1002/cjp2.140

Bartolomé-Casado R, Landsverk OJB, Chauhan SK, Richter L, Phung D, Greiff V, Risnes LF, Yao Y, Neumann RS, Yaqub S, Øyen O, Horneland R, Aandahl EM, Paulsen V, Sollid LM, Qiao SW, Baekkevold ES, Jahnsen FL (2019). Resident memory CD8 T cells persist for years in human small intestine. J Exp Med, 216 (10), 2412-2426. PubMed 31337737 DOI 10.1084/jem.20190414

Stankovic B, Bjørhovde HAK, Skarshaug R, Aamodt H, Frafjord A, Müller E, Hammarström C, Beraki K, Bækkevold ES, Woldbæk PR, Helland Å, Brustugun OT, Øynebråten I, Corthay A (2019). Immune Cell Composition in Human Non-small Cell Lung Cancer. Front Immunol, 9, 3101. PubMed 30774636 DOI 10.3389/fimmu.2018.03101

Cassetta L, Baekkevold ES, Brandau S, Bujko A, Cassatella MA, Dorhoi A, Krieg C, Lin A, Loré K, Marini O, Pollard JW, Roussel M, Scapini P, Umansky V, Adema GJ (2019). Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates. Cancer Immunol Immunother, 68 (4), 687-697. PubMed 30684003 DOI 10.1007/s00262-019-02302-2

2018

Høydahl LS, Richter L, Frick R, Snir O, Gunnarsen KS, Landsverk OJB, Iversen R, Jeliazkov JR, Gray JJ, Bergseng E, Foss S, Qiao SW, Lundin KEA, Jahnsen J, Jahnsen FL, Sandlie I, Sollid LM, Løset GÅ (2018). Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease. Gastroenterology, 156 (5), 1428-1439.e10. PubMed 30593798 DOI 10.1053/j.gastro.2018.12.013

van Bergenhenegouwen J, Braber S, Loonstra R, Buurman N, Rutten L, Knipping K, Savelkoul PJ, Harthoorn LF, Jahnsen FL, Garssen J, Hartog A (2018). Oral exposure to the free amino acid glycine inhibits the acute allergic response in a model of cow’s milk allergy in mice. Nutr Res, 58, 95-105. PubMed 30340819 DOI 10.1016/j.nutres.2018.07.005

Eguíluz-Gracia I, Malmstrom K, Dheyauldeen SA, Lohi J, Sajantila A, Aaløkken R, Sundaram AYM, Gilfillan GD, Makela M, Baekkevold ES, Jahnsen FL (2018). Monocytes accumulate in the airways of children with fatal asthma. Clin Exp Allergy, 48 (12), 1631-1639. PubMed 30184280 DOI 10.1111/cea.13265

Richter L, Landsverk OJB, Atlasy N, Bujko A, Yaqub S, Horneland R, Øyen O, Aandahl EM, Lundin KEA, Stunnenberg HG, Bækkevold ES, Jahnsen FL (2018). Transcriptional profiling reveals monocyte-related macrophages phenotypically resembling DC in human intestine. Mucosal Immunol, 11 (5), 1512-1523. PubMed 30038215 DOI 10.1038/s41385-018-0060-1

Poulsen LC, Edelmann RJ, Krüger S, Diéguez-Hurtado R, Shah A, Stav-Noraas TE, Renzi A, Szymanska M, Wang J, Ehling M, Benedito R, Kasprzycka M, Bækkevold E, Sundnes O, Midwood KS, Scott H, Collas P, Siebel CW, Adams RH, Haraldsen G, Sundlisæter E, Hol J (2018)nInhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory EnhancersnArterioscler Thromb Vasc Biol, 38 (4), 854-869nPubMed 29449332 DOI 10.1161/ATVBAHA.117.310388

2017

Bujko A, Atlasy N, Landsverk OJB, Richter L, Yaqub S, Horneland R, Øyen O, Aandahl EM, Aabakken L, Stunnenberg HG, Bækkevold ES, Jahnsen FL (2017)nTranscriptional and functional profiling defines human small intestinal macrophage subsetsnJ Exp Med, 215 (2), 441-458nPubMed 29273642 DOI 10.1084/jem.20170057

Engen SA, Schreurs O, Petersen F, Blix IJS, Baekkevold ES, Schenck K (2017)nThe Regulatory Role of the Oral Commensal Streptococcus mitis on Human MonocytesnScand J Immunol, 87 (2), 80-87nPubMed 29194752 DOI 10.1111/sji.12636

Jahnsen FL, Bækkevold ES, Hov JR, Landsverk OJ (2017). Do Long-Lived Plasma Cells Maintain a Healthy Microbiota in the Gut?. Trends Immunol, 39 (3), 196-208. PubMed 29162322 DOI 10.1016/j.it.2017.10.006

Malmström K, Lohi J, Sajantila A, Jahnsen FL, Kajosaari M, Sarna S, Mäkelä MJ (2017). Immunohistology and remodeling in fatal pediatric and adolescent asthma. Respir Res, 18 (1), 94. PubMed 28511697 DOI 10.1186/s12931-017-0575-0

Gudjonsson A, Lysén A, Balan S, Sundvold-Gjerstad V, Arnold-Schrauf C, Richter L, Bækkevold ES, Dalod M, Bogen B, Fossum E (2017). Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses. J Immunol, 198 (7), 2785-2795. PubMed 28228559 DOI 10.4049/jimmunol.1601881

Landsverk OJ, Snir O, Casado RB, Richter L, Mold JE, Réu P, Horneland R, Paulsen V, Yaqub S, Aandahl EM, Øyen OM, Thorarensen HS, Salehpour M, Possnert G, Frisén J, Sollid LM, Baekkevold ES, Jahnsen FL (2017). Antibody-secreting plasma cells persist for decades in human intestine. J Exp Med, 214 (2), 309-317. PubMed 28104812 DOI 10.1084/jem.20161590

2016

Jahnsen FL, Johansen FE, Haraldsen G (2016). Obituary – In Memoriam Per Brandtzaeg. Scand J Immunol, 84 (6), 370-372. PubMed 28025869 DOI 10.1111/sji.12505

Eguíluz-Gracia I, Schultz HH, Sikkeland LI, Danilova E, Holm AM, Pronk CJ, Agace WW, Iversen M, Andersen C, Jahnsen FL, Baekkevold ES (2016). Long-term persistence of human donor alveolar macrophages in lung transplant recipients. Thorax, 71 (11), 1006-1011. PubMed 27329043 DOI 10.1136/thoraxjnl-2016-208292

Schrøder M, Melum GR, Landsverk OJ, Bujko A, Yaqub S, Gran E, Aamodt H, Bækkevold ES, Jahnsen FL, Richter L (2016). CD1c-Expression by Monocytes – Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits. PLoS One, 11 (6), e0157387. PubMed 27311059 DOI 10.1371/journal.pone.0157387

Ballke C, Gran E, Baekkevold ES, Jahnsen FL (2016). Characterization of Regulatory T-Cell Markers in CD4+ T Cells of the Upper Airway Mucosa. PLoS One, 11 (2), e0148826. PubMed 26866695 DOI 10.1371/journal.pone.0148826

Eguíluz-Gracia I, Bosco A, Dollner R, Melum GR, Lexberg MH, Jones AC, Dheyauldeen SA, Holt PG, Bækkevold ES, Jahnsen FL (2016). Rapid recruitment of CD14(+) monocytes in experimentally induced allergic rhinitis in human subjects. J Allergy Clin Immunol, 137 (6), 1872-1881.e12. PubMed 26851967 DOI 10.1016/j.jaci.2015.11.025

George R, Santhanam S, Samuel R, Chapla A, Hilmarsen HT, Braathen GJ, Reinholt FP, Jahnsen F, Khnykin D (2015). Ichthyosis prematurity syndrome caused by a novel missense mutation in FATP4 gene-a case report from India. Clin Case Rep, 4 (1), 87-9. PubMed 26783444 DOI 10.1002/ccr3.462

2015

Krogvold L, Wiberg A, Edwin B, Buanes T, Jahnsen FL, Hanssen KF, Larsson E, Korsgren O, Skog O, Dahl-Jørgensen K (2015). Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes. Diabetologia, 59 (3), 492-501. PubMed 26602422 DOI 10.1007/s00125-015-3820-4

Skrindo I, Ballke C, Gran E, Johansen FE, Baekkevold ES, Jahnsen FL (2015). IL-5 production by resident mucosal allergen-specific T cells in an explant model of allergic rhinitis. Clin Exp Allergy, 45 (8), 1296-304. PubMed 25817862 DOI 10.1111/cea.12543

2014

Malmström K, Malmberg LP, O’Reilly R, Lindahl H, Kajosaari M, Saarinen KM, Saglani S, Jahnsen FL, Bush A, Haahtela T, Sarna S, Pelkonen AS, Mäkelä MJ (2014). Lung function, airway remodeling, and inflammation in infants: outcome at 8 years. Ann Allergy Asthma Immunol, 114 (2), 90-6. PubMed 25455519 DOI 10.1016/j.anai.2014.09.019

Jenum S, Grewal HM, Hokey DA, Kenneth J, Vaz M, Doherty TM, Jahnsen FL, TB Trials Study Group (2014). The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy indian adolescents. PLoS One, 9 (7), e101224. PubMed 24992314 DOI 10.1371/journal.pone.0101224

Melum GR, Farkas L, Scheel C, Van Dieren B, Gran E, Liu YJ, Johansen FE, Jahnsen FL, Baekkevold ES (2014). A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa. J Allergy Clin Immunol, 134 (3), 613-621.e7. PubMed 24958565 DOI 10.1016/j.jaci.2014.05.010

Danilova E, Skrindo I, Gran E, Hales BJ, Smith WA, Jahnsen J, Johansen FE, Jahnsen FL, Baekkevold ES (2014). A role for CCL28-CCR3 in T-cell homing to the human upper airway mucosa. Mucosal Immunol, 8 (1), 107-14. PubMed 24917456 DOI 10.1038/mi.2014.46

Bjerkan L, Schreurs O, Engen SA, Jahnsen FL, Baekkevold ES, Blix IJ, Schenck K (2014). The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide. Mucosal Immunol, 8 (1), 49-56. PubMed 24850429 DOI 10.1038/mi.2014.41

Solberg LB, Brorson SH, Stordalen GA, Bækkevold ES, Andersson G, Reinholt FP (2014). Increased tartrate-resistant Acid phosphatase expression in osteoblasts and osteocytes in experimental osteoporosis in rats. Calcif Tissue Int, 94 (5), 510-21. PubMed 24395179 DOI 10.1007/s00223-013-9834-3

2013

Hammerstad SS, Jahnsen FL, Tauriainen S, Hyöty H, Paulsen T, Norheim I, Dahl-Jørgensen K (2014)nImmunological changes and increased expression of myxovirus resistance protein a in thyroid tissue of patients with recent onset and untreated Graves’ diseasenThyroid, 24 (3), 537-44nPubMed 24032645 DOI 10.1089/thy.2013.0287

Hessle L, Stordalen GA, Wenglén C, Petzold C, Tanner E, Brorson SH, Baekkevold ES, Önnerfjord P, Reinholt FP, Heinegård D (2013). The skeletal phenotype of chondroadherin deficient mice nPLoS One, 8 (6), e63080. PubMed 23755099 DOI 10.1371/journal.pone.0063080

Brottveit M, Beitnes AC, Tollefsen S, Bratlie JE, Jahnsen FL, Johansen FE, Sollid LM, Lundin KE (2013). Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity. Am J Gastroenterol, 108 (5), 842-50. PubMed 23588237 DOI 10.1038/ajg.2013.91

Ráki M, Beitnes AC, Lundin KE, Jahnsen J, Jahnsen FL, Sollid LM (2013). Plasmacytoid dendritic cells are scarcely represented in the human gut mucosa and are not recruited to the celiac lesion. Mucosal Immunol, 6 (5), 985-92. PubMed 23340820 DOI 10.1038/mi.2012.136

2012

Lin C, Hindes A, Burns CJ, Koppel AC, Kiss A, Yin Y, Ma L, Blumenberg M, Khnykin D, Jahnsen FL, Crosby SD, Ramanan N, Efimova T (2012). Serum response factor controls transcriptional network regulating epidermal function and hair follicle morphogenesis. J Invest Dermatol, 133 (3), 608-617. PubMed 23151848 DOI 10.1038/jid.2012.378

Papadopoulos NG, Agache I, Bavbek S, Bilo BM, Braido F, Cardona V, Custovic A, Demonchy J, Demoly P, Eigenmann P, Gayraud J, Grattan C, Heffler E, Hellings PW, Jutel M, Knol E, Lötvall J, Muraro A, Poulsen LK, Roberts G, Schmid-Grendelmeier P, Skevaki C, Triggiani M, Vanree R, Werfel T, Flood B, Palkonen S, Savli R, Allegri P, Annesi-Maesano I, Annunziato F, Antolin-Amerigo D, Apfelbacher C, Blanca M, Bogacka E, Bonadonna P, Bonini M, Boyman O, Brockow K, Burney P, Buters J, Butiene I, Calderon M, Cardell LO, Caubet JC, Celenk S, Cichocka-Jarosz E, Cingi C, Couto M, Dejong N, Del Giacco S, Douladiris N, Fassio F, Fauquert JL, Fernandez J, Rivas MF, Ferrer M, Flohr C, Gardner J, Genuneit J, Gevaert P, Groblewska A, Hamelmann E, Hoffmann HJ, Hoffmann-Sommergruber K, Hovhannisyan L, Hox V, Jahnsen FL, Kalayci O, Kalpaklioglu AF, Kleine-Tebbe J, Konstantinou G, Kurowski M, Lau S, Lauener R, Lauerma A, Logan K, Magnan A, Makowska J, Makrinioti H, Mangina P, Manole F, Mari A, Mazon A, Mills C, Mingomataj E, Niggemann B, Nilsson G, Ollert M, O’Mahony L, O’Neil S, Pala G, Papi A, Passalacqua G, Perkin M, Pfaar O, Pitsios C, Quirce S, Raap U, Raulf-Heimsoth M, Rhyner C, Robson-Ansley P, Alves RR, Roje Z, Rondon C, Rudzeviciene O, Ruëff F, Rukhadze M, Rumi G, Sackesen C, Santos AF, Santucci A, Scharf C, Schmidt-Weber C, Schnyder B, Schwarze J, Senna G, Sergejeva S, Seys S, Siracusa A, Skypala I, Sokolowska M, Spertini F, Spiewak R, Sprikkelman A, Sturm G, Swoboda I, Terreehorst I, Toskala E, Traidl-Hoffmann C, Venter C, Vlieg-Boerstra B, Whitacker P, Worm M, Xepapadaki P, Akdis CA (2012). Research needs in allergy: an EAACI position paper, in collaboration with EFA. Clin Transl Allergy, 2 (1), 21. PubMed 23121771 DOI 10.1186/2045-7022-2-21

Hammerstad SS, Jahnsen FL, Tauriainen S, Hyöty H, Paulsen T, Norheim I, Dahl-Jørgensen K (2013). Inflammation and increased myxovirus resistance protein A expression in thyroid tissue in the early stages of Hashimoto’s thyroiditis. Thyroid, 23 (3), 334-41. PubMed 22998463 DOI 10.1089/thy.2012.0264

Reikvam DH, Derrien M, Islam R, Erofeev A, Grcic V, Sandvik A, Gaustad P, Meza-Zepeda LA, Jahnsen FL, Smidt H, Johansen FE (2012). Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice. Eur J Immunol, 42 (11), 2959-70. PubMed 22865203 DOI 10.1002/eji.201242543

Beitnes AC, Ráki M, Brottveit M, Lundin KE, Jahnsen FL, Sollid LM (2012). Rapid accumulation of CD14+CD11c+ dendritic cells in gut mucosa of celiac disease after in vivo gluten challenge. PLoS One, 7 (3), e33556. PubMed 22438948 DOI 10.1371/journal.pone.0033556